Render and disable your vsti!!! If you want to make chanes, re-enable, re-render and disable. Every single person I've seen complaining about instability and crashing seems to be running vsti heavy sessions, but after the track is laid down there is no need to keep loading the system with it.
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I guess when you're hardware is stretched to the limit something has to give. All the virtual instruments consume a lot of resources. I would personally try rendering out as much stuff as possible as audio files so you can be running less plugs in a session. Pro Tools probably won't help you unless you really spend a lot on hardware -- Reaper is way more efficient in my experience -- I was running/mixing about 50 tracks (many with plugins) on my last recording session on a pretty mediocre desktop machine and it held together till the end.
Getting Pro Tools to avoid stability issues? :D But yeah, some ppl had stability issues with at least ewql IIRC... try rendering those tracks and see if it helps.
Yes, freeze, render, and monitor your pc-load like read, write, cpu, ram. Any specific plugins that needs attention? Play with settings for that plugin. Buggy-mode, DFD-setting.
I felt similar for a while. In my case it was windows theme-patcher that caused reaper to crash frequently. Once I uninstalled it, reaper went back to normal.